LLMPP Mission:

The Lymphoma/Leukemia Molecular Profiling Project is using Lymphochip cDNA microarrays to define the gene expression profiles of all types of human lymphoid malignancies. One primary goal of this Project is to redefine the classification of human lymphoid malignancies in molecular terms. A second major goal is to define molecular correlates of clinical parameters which can be used in prognosis and in the selection of appropriate therapy for these patients.

For questions concerning the Lymphoma/Leukemia Molecular Profiling Project, contact:

Louis Staudt, M.D., Ph.D. or John Chan, M.D. jchan@unmc.edu

• Website companion to Dave, S et al. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tu mor-Infiltrating Immune Cells New England Journal of Medicine, Vol 351, 2159-2169 Nov 2004.

• Website companion to Wright, G et al. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma PNAS, Vol 100, 9991-9996, Aug 2003.

• Website companion to Rosenwald, A et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell, Vol 3, 185-197, Feb 2003.

• Website companion to Rosenwald, A et al. The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large B-Cell Lymphoma. New England Journal of Medicine, 346:1937-1947 (2002).

• Website companion to Rosenwald, A et al. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia. The Journal of Experimental Medicine, 149:1639-1667 (2001).

• Website companion to Alizadeh et al. Distinct Types of Diffuse Large B-Cell Lymphoma Identified By Gene Expression Profiling. Nature 403: 503-511 (2000).