Figure 2. Analysis of somatic mutations in the Ig VH genes in 28 CLL patients and correlation with their clinical courses A. VH gene usage and distribution of replacement and silent mutations in the complementarity determining regions (CDR) and framework regions (FW). # Most homologous to multiple cDNA sequences. B. Kaplan-Meier curve comparing the time from diagnosis to treatment between CLL patients with mutated and unmutated VH genes. Median time to treatment in Ig-mutated CLL: 95 months; median time to treatment in Ig-unmutated CLL: 28 months. The difference is significant at the p=0.001 level (log-rank test).