A. Hierarchical clustering of gene expression data for 205 array elements representing approximately 175 genes that were differentially expressed between mutated and unmutated CLL samples (p<0.001).
B.Hierarchical clustering of genes that most strongly discriminated between the CLL subtypes. Also shown for each gene is the ratio of mean expression of the gene in Ig-unmutated CLL samples (excluding CLL-60) versus mean expression in Ig-mutated (high) CLL samples, together with the p values (Student's t-test) that quantitate the significance of the difference in mean expression between the two CLL subtypes.
